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Pre-implantation diagnosis

Preimplantācijas diagnostika

Pre-implantation Genetic Testing of Embryos PGS/PGD (PGT-A/PGT-M)

The PGT-A and PGT-M methods not only enable the selection of the morphologically best and viable, but also chromosomally healthy embryos and thus increase the probability of the implantation and clinical pregnancy already after the first PGT-A/PGT-M cycle.

Pre-implantation Genetic Screening (PGS) or Pre-implantation Genetic Testing for Aneuploidy (PGT-A) allow to examine a 5-day embryo by using the NGS method (Next Generation Sequencing) to test all of the embryonic chromosomes simultaneously prior to the transfer of the embryo to the uterus, thus establishing the further development potential of the embryo and enabling to select an embryo with a normal set of chromosomes for the placement into the uterine cavity.

Indications:

  • Patients with recurringly unsuccessful IVF cycles
  • Patients with lost pregnancy
  • Couples with the age factor (females > 35 years of age, males > 45 years of age), due to more common development of sex cells with an altered set of chromosomes. Embryos developing from such sex cells are mostly unable to implant in the mucous membrane of the uterus, or their development stops during the first trimester of the pregnancy.
  • In patients with chromosomal structure alterations in their cells (Robertsonian or reciprocal translocation), these alterations may be the reason for years of infertility, recurringly lost pregnancies, or giving birth to a baby with a chromosomal abnormality.

PGS (PGT-A) is done:

  • To test all chromosomes for abnormalities
  • To improve the IVF outcome
  • To improve the IVF success rate
  • The testing requires no personalised preparation.

Pre-implantation Genetic Diagnosis (PGD) or Pre-implantation Genetic Testing for Monogenic Disorders / Single Gene Defects (PGT-M) – unique diagnosis for families:

  • With transgenerational inheritance of monogenic disorders (caused by single gene alterations);
  • With a child already having this disorder in the family;
  • If the woman or the man has a disorder on the level of their genes, it is possible to establish the exact location of the problem and to carry out an examination on the level of chromosomes and genes in order to exclude such health issues in the future child.

PGD (PGT-M) is done:

  • To reduce the risk of developing a genetic disease
  • To test for the risk of a monogenic disorder
  • The testing requires personalised preparation and design.

The Genetics Centre iVF Riga is currently the only centre in the Baltic States where pre-implantation genetic testing PGT-A/PGS and PGT-M/PGD can be done.

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